Accession Number:

ADA170852

Title:

Platelet Function in Basset Hound Hereditary Thrombopathy.

Descriptive Note:

Doctoral thesis,

Corporate Author:

AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s):

Report Date:

1986-01-01

Pagination or Media Count:

79.0

Abstract:

An inherited intrinsic platelet aggregation defect has been identified in Basset Hounds which clinically resembles the human disease, Glanzmanns thrombasthenia. The defect was named Basset Hound Hereditary Thrombopathy BHT and initial studies revealed variably prolonged bleeding times, normal blood coagulation parameters, normal platelet count and morphology, normal whole blood clot retraction, and an abnormal platelet aggregation response to adenosine diphosphate ADP. An evaluation of the specific platelet defect included simultaneous measurement of dense granule release and aggregation, two dimensional electrophoretic and crossed immunoelectrophoretic techniques in order to determine if the defect was associated with platelet membrane glycoprotein abnormalities, and measurement of radiolabeled fibrinogen binding to ADP stimulated platelets. An analysis of two-dimensional and crossed-immunoelectrophoretic gels revealed no abnormalities in platelet proteinglycoprotein content when affected Basset Hound platelets were compared to normal dog platelets.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE