Pharmacological Resetting of the Circadian Sleep-Wake Cycle.
Final technical rept. 1 Apr 83-31 Mar 86,
HARVARD MEDICAL SCHOOL BOSTON MA DEPT OF PHYSIOLOGY AND BIOPHYSICS
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This research program developed strategies to reset the timing of the circadian approximately 24-hour sleep-wake cycle so that individuals could be maintained fully awake in any predetermined time in the 24-hour day. This capability would be of direct benefit in minimizing the deleterious effects of jet-lag and could promote alertness in facilities which must be staffed 24 hours a day. The studies utilized a diurnal primate primate, the squirrel monkey Saimiri sciureus, with a well defined circadian neurophysiology and sleep-wake physiology. This animal has a consolidated sleep-wake cycle that is comparable to that in humans. During the three-year period of funding, the circadian sleep-wake organization in squirrel monkeys was characterized, and the rate of resynchronization after phase shifts of environmental light-dark cycles was determined.
- Anatomy and Physiology