Urinary Metabolites of Hydrazine in Male Fischer 344 Rats Following Inhalation or Intravenous Exposure
Final rept. Nov 1982-Mar 1984
HARRY G ARMSTRONG AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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The feasibility of developing an analytical method with urine to determine the extent of a workers exposure to hydrazine was studied. Urinary levels of hydrazine and two metabolites, monoacetylhydrazine and diacetylhydrazine, were identified and quantified from hydrazine-exposed male rats. The levels of hydrazine recovered from intravenous or inhalation exposures were compared. For all exposures, the majority of hydrazine was excreted during the first 24 hours and in acetylated forms. Urinary levels of hydrazines were very similar within each dose group.