Mechanisms of Rapid Nonspecific Resistence Induced by Immunomodulators: Delineation Using Selective Depletion of Cells.
Annual rept. 1 Jul 85-1 Jul 86,
MEDICAL COLL OF PENNSYLVANIA PHILADELPHIA DEPT OF MICROBIOLOGY AND IMMUNOLOGY
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A variety of immunomodulators have been evaluated in normal mice for ability to enhance nonspecific host resistance against herpes simplex virus type 2 HSV-2, encephalomyocarditis virus EMC, and Listeria monocytogenes. Several novel chemical immunomodulators were identified that had potent antiviral activity on prophylactic administration these included CL246,738, avridine in liposomes, and several pyrimidinones. In addition, repeated therapeutic administration of either alpha or gamma interferon was effective, particularly against HSV-2 infection. The mechanism of action of these agents will be investigated in mice selectively depleted of circulating monocytes and of NK cells by 89Sr treatment. We have previously shown that several immunomodulators are effective in 89Sr treated mice, suggesting a major role for tissue macrophage activation for their effects. The present results have also shown that treatment regimes effective against the viral infections may not be effective, or may even be adverse, against Listeria infection.
- Medicine and Medical Research