The Production of Rh sub 0 (D) Negative Erythrocytes.
Annual rept. 1 Jul 85-30 Jun 86,
NEW YORK BLOOD CENTER N Y
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Attempts are being made to modify or destroy the Rh D antigen under conditions which will produce Rh negative erythrocytes of transfusable quality. One of the approaches being taken involves the isolation and biochemical characterization of the D antigen in order to gather information which will help formulate ways of modifying its expression. To this end we have progressed toward establishing a 28-32 Kd membrane protein as the primary D antigen. This is evidenced by its ability under certain conditions to induce antibody toward Rh positive cells and when attached to plates to yield a positive reaction with human anti-D in the ELISA assay.
- Medicine and Medical Research