Accession Number:

ADA170483

Title:

The Production of Rh sub 0 (D) Negative Erythrocytes.

Descriptive Note:

Annual rept. 1 Jul 85-30 Jun 86,

Corporate Author:

NEW YORK BLOOD CENTER N Y

Personal Author(s):

Report Date:

1986-07-18

Pagination or Media Count:

3.0

Abstract:

Attempts are being made to modify or destroy the Rh D antigen under conditions which will produce Rh negative erythrocytes of transfusable quality. One of the approaches being taken involves the isolation and biochemical characterization of the D antigen in order to gather information which will help formulate ways of modifying its expression. To this end we have progressed toward establishing a 28-32 Kd membrane protein as the primary D antigen. This is evidenced by its ability under certain conditions to induce antibody toward Rh positive cells and when attached to plates to yield a positive reaction with human anti-D in the ELISA assay.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE