Accession Number:

ADA170368

Title:

Evaluation of Pharmacologic Agents to Suppress Intraocular Cellular Proliferation Following Trauma. Revision.

Descriptive Note:

Annual rept.,

Corporate Author:

MICHIGAN STATE UNIV EAST LANSING DEPT OF SURGERY

Report Date:

1986-07-01

Pagination or Media Count:

28.0

Abstract:

In an animal model of tractional retinal detachment using both labeled and unlabeled retinal pigment epithelial cells, we determined that methyltrexate and 5-FU were the most effective currently considered pharmacologic agents for the suppression of intraocular cellular proliferation based upon suppression of clinical tractional retinal detachments. Following trauma to the eye intracular cellular proliferation is the most common cause of tractional retinal detachment and subsequent loss of the globe if the eye survives the initial trauma. This study has been designed to test various pharmacologic agents to suppress intraocular cellular proliferation and reduce tractional retinal and ciliary body detachment and subsequent loss of the eye from either retinal detachment or cyclitic membrane formation. The course of years activity centered around evaluation of the model induced tractional retinal detachments in both control eyes and eyes treated with the pharmacologic agents triamcinolone, dexamethasone prostaglandin PGE1, methyltrexate, 5-FU and colchicine. The eyes were studied in a gross and light microscopic fashion in addition to transmission electron microscopy.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE