Dose Level Effects of Triazolam on Sleep and Response to a Smoke Detector Alarm.
Final rept. 1979-1985,
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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Thirty-six young adult, male subjects with sleep-onset insomnia were equally divided into placebo, .25 mg and .50 triazolam groups to examine the effects of the hypnotic, with particular attention to dose level, on efficacy, sleep stages, and awakening to a smoke detector alarm. On nights 1 and 4 of a five-consecutive night protocol, a standard home smoke detector alarm was sounded during Stage 2, 5 minutes after sleep onset, in slow wave sleep SWS, and at the time of the early morning awakening. The alarm registered 78 dB at the pillow. EEG arousal latency and reaction time to a button press were studied. Failure to awaken to three one-minute alarm presentations was scored as no response. Both dose levels produced similar reduction in sleep latency, decrease in SWS, increase in Stage 2, and increase in sleep latency. Both dose levels showed a similar sedative effect to the smoke alarm. Fifty percent failed to awaken on night 1 during SWS, and EEG arousal and response latencies were significantly slowed. Some tolerance was seen by night 4. By morning, all subjects were easily awakened on both nights. The .25 mg dose is clearly an effective dose level for both sleep efficacy and sedative effects to outside noise. The sedative effects, in some instances, could pose a potential problem.