Accession Number:

ADA170129

Title:

Endocrine and Pulmonary Response to Hemorrhagic Shock.

Descriptive Note:

Annual progress rept. 1 Oct 75-30 Sep 76,

Corporate Author:

BOSTON UNIV MA SCHOOL OF MEDICINE

Report Date:

1976-09-30

Pagination or Media Count:

22.0

Abstract:

Control and pancreatectomized-adrenalectomized rhesus monkeys were shown to exhibit comparable urinary nitrogen excretion rates and to have similar levels of metabolic dysfunction in isolated skeletal samples. Nutritional support with 50 percent dextrose with sufficient insulin to prevent hyperglycemia profoundly altered the metabolism of subsequently isolated skeletal muscle and prevented the induction of a nitrogen catabolic state by hemorrhagic shock. Subclassifications of acute respiratory failure based on pathophysiologic alterations are described. In animal work, changes following the infusion of oleic acid may be distinguished from E. coli. In humans, the lung changes following aneurysm surgery are different from those seen with sepsis. The metabolic functions of the lungs have been examined and found to be causative in inducing cardiac depression with high levels of PEEP.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE