Immune Dysfunctions and Abrogation of the Inflammatory Response by Environmental Chemicals.
Final rept. 1 Jul 83-31 Dec 85,
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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During this reporting period, further examples of 1,1-dimethylhydrazine UDMH induced immunoenhancment have been noted, and at least two possible mechanisms for immunoenhancement have been suggested. First, in vivo or in vitro exposure to UDMH results in enhancement of the allogeneic mixed lymphocyte response, a measure of cell mediated immunity. Interference of certain macrophage functions by UDMH has been demonstrated, such as decreased prostaglandin E2 production and chemiluminescence. Inhibition of these properties which are associated with macrophage-related immunosuppression could explain the immunoenhancement induced by UDMH. Preliminary experiments also suggest that UDMH enchances interleukin 1 production by macrophages and interleukin 2 activity on cell proliferation, but that it inhibits interleukin 1 activity.
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