Accession Number:

ADA169814

Title:

Pharmacology of Periodontal Disease.

Descriptive Note:

Annual letter rept.,

Corporate Author:

UNIVERSITY OF HEALTH SCIENCES/CHICAGO MEDICAL SCHOOL IL DEPT OF PHARMACOLOGY

Personal Author(s):

Report Date:

1986-06-23

Pagination or Media Count:

18.0

Abstract:

This research pertains to identifying antibacterial and antiinflammatory agents, used individually or in combination, which are appropriate for preventing the exacerbation of acute periodontal disease under field conditions. During the second year of the contract researchers have continued studies using the human polymorphonuclear leukocyte PMN as a model system. One of the assays planned to be used for these drug evaluations Phagocytosis Assay has demonstrated an excessive amount of variability that assay has been discarded. In its place we have added a very sensitive assay for PMN Superoxide production, which is one of the primary mechanisms by which PMNs destroy bacteria. Excessive production of superoxide radicals may also cause damage to normal healthy tissues. Some older antibacterial and anti-inflammatory compounds have been examined with regard to our objectives, and we have focused on more recently marketed compounds.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE