Genotoxicity and Carcinogenesis: A Brief Survey
Special publication Jan-Aug 1984
CHEMICAL RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUNDMD
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Much of the recent research into the mechanisms and causes of cancer has dealt with the genetic aspects of carcinogens, particularly on somatic cells. Organic compounds that invade the body are usually metabolized and excreted however, a small percentage react with DNA and other cellular macromolecules. If the damaged genome is not repaired, mutations may result that occassionally lead to malignant transformation. Because of the cost both time as well as monetary of testing animals, short-term assays have been developed that measure the different effects of agents on cells, therefore providing data for predicting the genotoxicity in vivo.
- Chemical, Biological and Radiological Warfare