Metabolism of Nephrotoxic cis- and Trans-Decalin in Fischer-344 Rats,
WRIGHT STATE UNIV DAYTON OH DEPT OF CHEMISTRY
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The cis- and trans-decalin stereoisomers have found many uses as solvents and fuel components. The metabolism of the decalin isomers in male and female Fischer-344 rats and the effects of the decalins on renal damage were evaluated. Only male rats had kidney damage. Metabolism of cis-decalin yielded cis-trans-1-decalol and cis,cis-2-decalol in the urine of both sexes, with the male also producing cis, cis-1-decalol. The urinary metabolites of trans-decalin included trans, cis-2-decalol in both male and female rats and trans, trans-1- decalol in males. Extracts of kidney homogenates from male rats, but not females, dosed with cis- and trans-decalin yielded cis-2-decalone and trans-2- decalone, respectively. A single male rat treated with trans-decalin produced no 2-decalone in the kidney extract and also showed no renal damage.