Carbamate Induced Performance Decrement Restored with Diazepam and Atropine in Rats,
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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When rats 500g, male are exercised to exhaustion on a treadmill, pretreatment with the carbamate physostigmine reduces endurance capacity. Our objective was to determine whether pharmacological intervention could reverse these decrements in performance. The following drugs were administered separately via tail vein vehicle-control C, atropine 200 ugkg, A, diazepam 500 ugkg, D, and physostigmine 200 ugkg, PH. After drug administration, rats were run 11 mmin, 6 deg elevation, Ta 26 c to exhaustion unable to right themselves when placed on their backs. PH administration resulted in reduced endurance 41 min PH vs 53 min C, P.05 with greater increments in core temperature 0.090 Cmin PH vs 0.057 Cmin C, p.01 than control rats. However, when A and D were also given to PH treated rats, the run time and heating rate were restored to control levels. Further, A and D without PH improved performance 82 min, 0.047 Cmin over control levels. Serial administration of an anticholinergic, an anticonvulsant, and an anticholinesterase resulted in no significant change in performance from control levels. Keywords Temperature regulation Heat stress.
- Anatomy and Physiology
- Stress Physiology