Accession Number:

ADA168584

Title:

Viral Hemorrhagic Fever,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s):

• Peters,C. J.
• Shelokov,Alexis

Report Date:

1986-01-01

Pagination or Media Count:

4.0

Abstract:

Several RNA viruses transmitted to humans from animals or arthropods may cause a syndrome referred to as viral hemorrhagic fever or VHF. The target organ for the VHF syndrome is the fascular bed correspondingly, the dominant clinical features are usually related to microvascular damage and changes in vascular permeability. Common presenting complaints are fever, myalgia, and prostration clincal examination may reveal only conjuctivits, mild hypotension, flushing, and petechial hemorrhages. Full-blown VHF typically proceeds to shock and generalized mucous membrane hemorrhage and is often accompanied by evidence of neurologic, hematopoietic, or pulmonary system involvement. Hepatic involvement is common, but a clinical picture dominated by jaundice and other evidence of hepatic failure is only seen in some cases of Rift Valley fever, Congo-Crimean HF, marburg HF, Ebola HF, and yellow fever. Renal failure is proportional to cardiovascular compromise, except in hemorrhagic fever with renal syndrome HFRS, where it is an integral part of the syndrome. Mortality is substantial, ranging from 5 to 20 percent or higher in recognized cases.

Descriptors:

• *HEMORRHAGIC FEVERS
• *VIRUS DISEASES
• *PATHOGENESIS
• *EPIDEMIOLOGY
• REPRINTS
• PERMEABILITY
• HUMANS
• FAILURE
• SIGNS AND SYMPTOMS
• LUNG
• ANIMALS
• RIFT VALLEY FEVER
• VIRUSES
• CARDIOVASCULAR SYSTEM
• LIVER DISEASES
• KIDNEYS
• HEMORRHAGE
• ARTHROPODA

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE