Accession Number:

ADA168143

Title:

Investigations Regarding Anesthesia during Hypovolemic Conditions.

Descriptive Note:

Annual summary rept. no. 2, 26 Sep 81-25 Sep 82,

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s):

Report Date:

1982-09-25

Pagination or Media Count:

136.0

Abstract:

This research attends to unmet requirements in the physiological management of moderately and severely wounded soldiers, thereby a improving the return-to-duty rate of the combat-injured, and c reducing resource primarily material and logistical support utilization by Army medical field facilities. The research examines the interaction of anesthetic agents appropriate for use in a combat environment, with hemorrhage. In doing so, the physiology of hemorrhage the physiological processes that contribute to the differences among anesthetic agents for induction and maintenance of anesthesia during hemorrhage will be examined. Swine are used as the experimental model, examining rationale and physiology of use of nitrous oxide, enflurane, isoflurane, halothane, thiopent and ketamine for induction of anesthesia during the hypovolemic condition. We have characterized the awake swine response to hemorrhage, and defined the swines blood acid-base chemistry. During hypovolemia, induction of anesthesia with either ketamine or thiopental causes similar, important deterioration of cardiovascular compensation for moderate hemorrhage. Keywords Combat casualty management Renin-angiotensin.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE