Acute Oral Toxicity of (E)-1,2,3,4-Tetrahydro-6-Methyl-1-(2-Methyl-1- Oxo-2-Butenyl) Quinoline (CHR5) in Male and Female Rats
Final rept. 18 Nov-16 Dec 1983, 25 Apr-16 May 1984
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The acute oral toxicity of E-1,2,3,4-tetrahydro-6-methyl-1-2- methyl-1-Oxo-2-Butenyl Quinoline CHR5 was determined in Sprague-Dawley rats by using the oral gavage single-dose method. The LD50 was 2.73 gkg for male rats and 2.22 gkg for female rats. CHR5 produces a syndrome of general malaise and appears to target the upper gastrointestinal tract and the central nervous system. The predominate GFI sign was increased salivation. CNS signs included loss of equilibrium, twitching, tremors, hypotonia, and depression of the grasping, pinch, pull, and righting reflexes.