Accession Number:

ADA167600

Title:

Mortality of Munitions Workers Exposed to Dinitrotuluene

Descriptive Note:

Final rept. Jul 1980-Jan 1986

Corporate Author:

CHEMICAL INDUSTRY INST OF TOXICOLOGY RESEARCH TRIANGLE PARK NC

Report Date:

1986-01-01

Pagination or Media Count:

39.0

Abstract:

To determine whether the carcinogenicity of dinitrotoluene DNT in rodent bioassays had relevance for humans, we examined the mortality experience of exposed workers at two ammunition plants. Cohorts of 156 and 301 men who had worked a month or more during the 1940s and 1950s at jobs with opportunity for substantial DNT exposure were followed through the end of 1980. Numbers of expected deaths and standardized mortality ratios SMRs were computed, using mortality rates of U.S. white males as the standard. No evidence of a carcinogenic effect was found, but unsuspected excesses of mortality from ischemic heart disease were noted at both plants SMRs 143 an 131 95 confidence limits 65-234 and 107-187, respectively. Deaths from ischemic heart disease remained high even when compared to expected numbers derived using mortality rates of the counties in which the plants were located. Additional analyses revealed evidence of a 15 year latent period and suggested a relationship with duration and intensity of exposure. Epidemiological investigations of other heavily exposed populations are needed to confirm the etiological significance of the association between DNT and heart disease described here. Keywords Ammunition Arteriosclerosis Neoplasms and Occupational diseases.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Ammunition and Explosives
  • Environmental Health and Safety

Distribution Statement:

APPROVED FOR PUBLIC RELEASE