Modification of WR 2721 of Acute and Chronic Effects of Radiation Injury to the Lung.
Annual rept. 1 Sep 83-31 Jan 84,
DUKE UNIV DURHAM NC
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The purpose of the work was to study WR2721, without without corticosteroids, on acute and chronic lung injury caused by a sublethal dose of ionizing radiation. The model used was that of 3000 rads unilateral radiation to the left lung of adult rats. The degree of injury and the amount of protection were to be assessed at 12 weeks, 26 weeks and 52 weeks post-radiation by quantitative ultrastructural examination and physiologic measurements. We have completed morphometric studies on the animals sacrificed at 12 weeks post-radiation. WR2721 by itself did not confer significant protection at this time point. However, WR2721 plus corticosteroids significantly protected against changes in the interstitium there was also a trend towards protection of the vascular compartment. At 26 weeks post-radiation, studies have been completed on 1 animal in each experimental group. The changes in the radiated animal were more severe than at 12 weeks WR2721 seemed to allow improvement of the changes seen at 12 weeks and WR2721 and corticosteroids had an even more striking protective effect.