Accession Number:

ADA165868

Title:

Thermoregulation After Atropine and Pralidoxime Administration,

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1986-03-01

Pagination or Media Count:

19.0

Abstract:

The effects of intramuscular saline control, atropine 2mg, pralidoxime 600 mg or a combination of the two drugs on heat exchange was evaluated in four healthy males during moderately intense seated, cycle exercise 55 v02 peak in a temperate environment T sub a 30.3 C, P sub W 1.0 kPa. Esophageal, rectal, and mean skin temperatures, and chest and forearm sweating were continuously measured. Skin blood flow FBF from the forearm was measured twice each minute by venous occulusion plethysmography. Whole body sweating was calculated from weight changes. The expected result of atropine injection, decreased eccrine sweating -60, P 0.05 with ensuent elevated esophageal 0.4C, P0.05 and skin temperature 2.1C, P0.05 was observed relative to control. Heart rate 28 bmin and FBF 9 ml100cc were higher after atropine. Pralidoxime, in general, did not affect the core and skin temperature responses to the exercise differently from control however, a slightly elevated FBF 3ml100cc min, 33 compensated for the reduction in whole body sweating -45, p0.05 that we observed. The combination of the drugs resulted in significantly higher esophageal 0.4C and skin 0.9C temperatures than atropine alone, as has been previously shown. The thermoregulatory disadvantage of inhibited sweating by atropine was partially compensated for by enhanced skin blood flow in this environment where T sub aT sub sk. Pralidoxime was shown to decrease whole body sweating, by a mechanism as yet unexplained. Keywords Anticholinergics.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE