Accession Number:

ADA164972

Title:

Oral Pyridostigmine Administration in Rats: Effects on Thermoregulation, Clinical Chemistry, and Performance in the Heat

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1984-01-01

Pagination or Media Count:

24.0

Abstract:

We have recently reported that acute intraperitoneal administration of pyridostigmine bromide to rats resulted in significant decrements in physical performance in the heat, adverse thermoregulatory effects, and exacerbated elevations in several indices of heatexercise injury. To simulate anticipated human use of this carbamate as a prophylaxis for organophosphate poisoning, pyridostigmine was dissolved in the drinking water of rats. Consumption of pyridostigmine for 7 days n34, 6.6 mgday resulted in a 23 p.001 reduction of circulating cholinesterase when compared with a control group n31 while ingestion for 14 days n35, 8.9 mgday elicited a 39 p .001 inhibition of circulating cholinesterase when compared to a second control group n33. Water and food consumption, rate of weight gain, and overt behavior were unaffected by pyridostigmine consumption. When approximately half the animals in each group were exercised 9.14 mmin in the heat 35 C to hyperthermic exhaustion Tre 42.5-43 C, rats unable to right themselves, pyridostigmine consumption for 14 days effected a significantly p .05 increased rate of weight water loss, but no further effects on thermoregulation or performance were noted. We have concluded from these studies that administration of pyridostigmine in the drinking water of animals may be a quantitative and suitable means to simulate oral consumption in humans.

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE