Acute Oral Toxicity (LD50) of Guanidine Hydrochloride in Rats
Final rept. 19 Jan-14 Feb 1984
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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Nitroguonidine is being evaluated by the US Army as a replacement for the nitrocellulose component of certain propellantsmunitions. The acute oral toxicity of guanidine hydrochloride was determined in male and female Sprague-Dawley rats by using the oral gavage single-dose method. The LD50 or - S.E. for male rats was 556.5 or - 29.7 mgbasekg and 474.6 or - 35.3 mgbase kg for female rats. Clinical signs were observed in both the gastrointestinal GI tract and the central nervous system-neuromuscular junction CNS-NM. Symptoms referable to the GI tract included increased salivation, hunched posture, and diarrhea. CNS-NM signs included disorientation, increased startle reflex, hyperactivity, jumping behavior, presence of tremorstwitching and depression of grasping and righting reflexes. These results place guanidine hydrochloride in slightly toxic and moderately toxic ranges respectively.