Accession Number:

ADA164573

Title:

Investigation of T-2 Mycotoxin-Induced Cytotoxicity in Vitro and Protective Effects of Flavonoid Compounds.

Descriptive Note:

Memorandum rept.,

Corporate Author:

DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)

Report Date:

1986-01-01

Pagination or Media Count:

25.0

Abstract:

Aspects of the in vitro cytotoxic effects of T-2 mycotoxin on murine thymocytes were investigated. Cytotoxicity was found to be consistent when tested bi-weekly for a four month period. Cytotoxicity reached maximal values over a narrow range of doses and was dependent on temperature 37 C optimum and number of cells in the reaction mixtures. Quercetin, a flavonoid compound was able to decrease the effect of T-2 toxin when the drug was added within an hour of mixing the T-2 toxin with the thymocytes.

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE