Investigation of T-2 Mycotoxin-Induced Cytotoxicity in vitro and Protective Effects of Flavonoid Compounds
DEFENCE RESEARCH ESTABLISHMENT SUFFIELDRALSTON (ALBERTA)
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Aspects of the in vitro cytotoxic effects of T-2 mycotoxin on murine thymocytes were investigated. Cytotoxicity was found to be consistent when tested bi-weekly for a four month period. Cytotoxicity reached maximal values over a narrow range of doses and was dependent on temperature 37 C optimum and number of cells in the reaction mixtures. Quercetin, a flavonoid compound was able to decrease the effect of T-2 toxin when the drug was added within an hour of mixing the T-2 toxin with the thymocytes.