Calcium Antagonist and Heat-Induced Hepatic Injury,
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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Isolated perfused rat livers exposed to 42 C for 90 minutes produce membrand changes which appear to be similar to those induced by toxic chemicals or hypoxia. Three calcium antagonists nifedipine, dantrolene, and verapamil which have been reported to reduce irreversible cell injury were separately included in perfusates of moderately heated livers. Potassium and transaminase leakage, bile production and ultrastructure were used to compare heated livers perfused with and without Ca2 antagonists. Neither of these Ca2 antagonist improved the ultrastructure or function of the heated livers however, dantrolene produced detailed vesicular endoplasmic reticulum while verapamil produced vesicular endoplasmic reticulum and unique ring-shaped mitochondria. These changes indicated selective intracellular action on membranes of heated liver cells without protective effects.
- Medicine and Medical Research