Comparison of the Effects of Soluble and Particulate Forms of Glucan, an Immunomodulator, on Prostaglandin Synthesis by Rat Peritoneal Macrophages
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Pagination or Media Count:
GLUCAN, AN IMMUNOMODULATOR derived from the yeast Saccharomyces cervesiae, exists in two preparations, particulate glu-P and soluble glu-F. Both preparations enhance host antibacterial and antineoplastic resistance. Unlike glu-F, glu-P is associated with granulomatous reactions within the reticuloendothelial system RES and endotoxin sensitivity. Since some of the adverse effects of glu-P may be mediated by prostaglandins PGs, we compared the effects of glu-P and glu-F on PG production by rat peritoneal macrophages PMos.