Accession Number:

ADA164185

Title:

Comparison of the Effects of Soluble and Particulate Forms of Glucan, an Immunomodulator, on Prostaglandin Synthesis by Rat Peritoneal Macrophages

Descriptive Note:

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1985-01-01

Pagination or Media Count:

3.0

Abstract:

GLUCAN, AN IMMUNOMODULATOR derived from the yeast Saccharomyces cervesiae, exists in two preparations, particulate glu-P and soluble glu-F. Both preparations enhance host antibacterial and antineoplastic resistance. Unlike glu-F, glu-P is associated with granulomatous reactions within the reticuloendothelial system RES and endotoxin sensitivity. Since some of the adverse effects of glu-P may be mediated by prostaglandins PGs, we compared the effects of glu-P and glu-F on PG production by rat peritoneal macrophages PMos.

Subject Categories:

  • Biochemistry
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE