Accession Number:

ADA164085

Title:

Effect of Ambient Temperature on the Toxicity of Palmitoyl Glycerol.

Descriptive Note:

Final rept. 1981-1985,

Corporate Author:

NORTH CAROLINA STATE UNIV AT RALEIGH

Personal Author(s):

Report Date:

1985-11-25

Pagination or Media Count:

7.0

Abstract:

Palmitoyl glycerol and myristoyl glycerol are toxic when fed to mice. The symptoms are hypothermia, death, and poor growth by the survivors. The toxicity is greatly exacerbated at low ambient temperatures, and is prevented if the diet is supplemented with small amounts of unsatured fatty acids. Lymph and plasma lipids from mice fed palmitoyl glycerol contain more than 75 saturated fatty acids. The mechanism of the toxicity is not understood, but may involve the alteration of some membrane lipids so that a vital function is impaired.

Subject Categories:

  • Biochemistry
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE