The Experimental Determination of Safe Atmospheric Exposure Concentrations of JP-10 Jet Fuel
Final technical rept. Jun 1978-Jun 1984
CALIFORNIA UNIV DAYTON OH
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Four animal species were exposed for 1 year to 100 ppm 556 cu mgm JP-10 to determine its long-term toxic and oncogenic effects. Rats, mice, and hamsters were maintained for 1 year postexposure, while dogs were held for 5 years postexposure. Mean body weights of exposed hamsters and make rats were lower than controls during exposure. Weight recovery occurred in hamsters, but not in male rats during postexposure phase of the study. Significant JP-10 exposure related effects were renal tubular nephrosis together with an increase in benign and malignant renal cell tumors in male rats.