Accession Number:

ADA162996

Title:

Effect of Adjuvants on Response to Pneumococcal Polysaccharide Injected Intraperitoneally. Platelet-Derived Immunoregulatory Activity

Descriptive Note:

Annual rept. 1 Jul 1984-15 Dec 1985

Corporate Author:

NEW YORK UNIV MEDICAL CENTER NY DEPT OF PATHOLOGY

Personal Author(s):

Report Date:

1985-12-15

Pagination or Media Count:

21.0

Abstract:

Studies on the immunoaugmenting effect of a platelet-derived serum factor were extended to include 1 identification of the factor as the alpha- granule constituent known as platelet factor 4. The cells with affinity for this factor were identified as Ly2, Ly22, Qa1, QA4, Qa5, Ly6 and Ly1-, L3T4-, Thyl cells. Effects of PF4, detoxified endotoxin, IgD and 8-mercaptoguanosine on antibody production to pneumococcal polysaccharides types 3 and 14 were examined. Two aspects are being studied separately a enhancement of the response which is particularly good with endotoxin injected 4 days after antigen and b prevention of the tolerizing effect of slightly higher than optimal doses of polysaccharaide which may be possible with the platelet factor.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE