Animal Models for the Prevention of Acute and Chronic Graft-versus-Host Disease.
Annual rept. Sep 82-Sep 83, Final rept. 15 Sep 81-31 Dec 83,
CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
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These studies considered the effect on monoclonal antibodies to several T-cell differentiation antigens on graft-versus-host disease in a murine model of bone marrow transplantation. The monoclonal antibodies were used for in vitro treatment of bone marrow andor spleen cells prior to transplantation and were also used to treat established graft-versus-host disease by in vivo injections. The results increase our understanding of transplantation biology and can form the basis for clinical studies.
- Medicine and Medical Research