Nonspecific Resistance Induced by an Immunopharmacologic Agent Derived from Bordetella pertussis
Annual rept. no. 2, Aug 1984-Aug 1985
ALABAMA UNIV UNIVERSITY DEPT OF MICROBIOLOGY
Pagination or Media Count:
Administration of Bordetella pertussis vaccine intraperitoneally induces resistance to mouse adenovirus infection. Subcellular fractions of B. pertussis are capable of inducing resistance also. Boivin antigen, a trichloroacetic acid-soluble extract of whole cells, is capable of inducing resistance in the dose range of 0.2-2.0 ug when adsorbed to alum. Biochemical analysis of Boivin antigen indicated that the lipopolysaccharide and protein components were not complexed, but were co-extracted. the lipopolysaccharide endotoxin moiety was responsible for the antiviral activity and the endotoxin- associated proteins potentiated the antiviral effect.
- Medicine and Medical Research