Accession Number:

ADA162530

Title:

A Platelet-Derived Immunoregulatory Serum Factor with T Cell Affinity,

Descriptive Note:

Corporate Author:

SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Report Date:

1985-05-01

Pagination or Media Count:

5.0

Abstract:

A factor in mouse and human serum which enhances immune responses to Sheep erythrocytesSRBC and Total Net PositiveTNP-Ficoll in mice has been described. This factor completely reverses immunosuppression induced by syngeneic lymphoma RCS or allogeneic lymph node cells. T lymphocytes bind this factor, since the activity can be removed from serum by absorption with T cell containing spleen cells or cloned cytotoxic T lymphocytes. Furthermore, the factor is active only in the presence of mature T cells. Platelet alpha-granules seem to be the source of this serum factor because 1 the activity is lacking in plasma, in serum prepared in the absence of platelets, and in serum prepared from a patient lacking platelet alpha-granules and 2 isolated mouse or human platelets release an immunostimulatory factor with very similar properties upon incubation with thrombin.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE