Accession Number:

ADA162488

Title:

Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice,

Descriptive Note:

Corporate Author:

MINNESOTA UNIV DULUTH

Report Date:

1985-01-01

Pagination or Media Count:

5.0

Abstract:

Sera from mice which have been injected iv with either polyA polyU or polyI-polyC 1 12 hr prior to bleeding were found to suppress the mixed lymphocyte reaction. This effect was reduced considerably by 18 hr. Characterization of the suppressive sera revealed it a was stable to heating at 56 C for 1 hr and freezing at -20 C for 1 month b had a molecular weight greater than 30,000 c could be induced in sera from athymic nude mice and d was present to a lower degree in sera from aging mice.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE