Suppression of the Mixed Leukocyte Reaction by Serum from Polynucleotide-Injected Mice,
MINNESOTA UNIV DULUTH
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Sera from mice which have been injected iv with either polyA polyU or polyI-polyC 1 12 hr prior to bleeding were found to suppress the mixed lymphocyte reaction. This effect was reduced considerably by 18 hr. Characterization of the suppressive sera revealed it a was stable to heating at 56 C for 1 hr and freezing at -20 C for 1 month b had a molecular weight greater than 30,000 c could be induced in sera from athymic nude mice and d was present to a lower degree in sera from aging mice.
- Anatomy and Physiology
- Medicine and Medical Research