Development of an Ultrafast-Curing Wound Dressing
Annual rept. 30 Sep 1983-30 Sep 1984
THERMEDICS INC WOBURN MA
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This document describes a second-generation, drug-dispensing wound dressing. The wound dressing, which can be applied by the wounded soldier himself, incorporates thrombin as a coagulant to stop bleeding, and gentamycin sulfate as a wide-spectrum antibiotic to prevent bacterial infection. The new would dressing is a trilaminate composite. The air side of the trilaminate is a fabric impregnated with an aliphatic, medical grade polyurethane elastomer the middle laminate is a controlled release layer, containing the microencapsulated pharmacoactive agents, and the third laminate is a 1.0-mil-thick layer of acrylic-based, pressure-sensitive adhesive. The middle layer is fabricated from a mixture of urethane and silicone oligomers, which are precompounded with pharmacoactive agents, and is subsequently solidified cured upon mere exposure to low-intensity UV radiation at room temperature. Solidification at room temperature is a vital consideration, because most drugs are rapidly inactivated upon mild heating. Once cured, the oligomer layer containing pharmacoactive agents becomes a controlled-release monolith, capable of dispensing drugs at a continuous and predictable rate.
- Medical Facilities, Equipment and Supplies