Chemotherapy of Rodent Malaria.
Final rept. 1 Oct 82-30 Sep 83,
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE (ENGLAND) DEPT OF MEDICAL PROTOZOOLOGY
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The report describes antimalarial studies performed on 63 compounds, mainly supplied by WRAIR, to determine blood schizontocidal, causal prophylactic and gametocytocidal activity. Data from tests on a range of putative primaquine metabolites are included. The development is described of two lines of Plasmodium berghei resistant to the Mannich base, WR228258. Mode of action studies on this compound, on a second Mannich base - WR194965 and on an 8-aminoquinoline, WR225448, are reported. Keywords Plasmodium yoelii nigeriensis Resistance biology Floxacrine Quinine Phenanthrene alcohols Mefloquine Saframycin A Clopidol. Author