Antiemetic Drugs and Pilot Performance.
Interim rept. Feb 83-Feb 84,
ILLINOIS UNIV AT URBANA-CHAMPAIGN SAVOY INST OF AVIATION
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This study evaluated the effects on human performance of three antiemetic drugs. The effects on pilot performance in a flight simulator were determined using the commonly prescribed dosages, standardized for a 70 kg person, of thiethylperazine 10 mg, promethazine hydrochloride 25 mg cimetidine 300 mg, and a placebo control. Two tasks, a two-dimensional tracking task which part of an instrument landing system ILS approach and the Sternberg choice reaction time task, were used to generate pilot performance data. A Latin square design was used to balance treatment order effects, and each subject received each treatment condition. Log root mean square RMS deviation values, computed from the simulator flight data altitude straight and level, altitude turning, localizer lateral tracking, glideslope vertical tracking were used in a multivariate analysis of variance to test the main effects. An approximate F-test, based on Wilks criterion, resulted in F12,87 2.47, P0.0008 for the treatment main effect drug. Univariate analyses resulted in a significant drug main effect on two primary task variables--altitude straight and level and localizer tracking. Contrasts between the three antiemetic drugs and the placebo were used to test the hypothesis of no significant difference between treatment pairs. The contrasts between promethazine hydrochloride and the control were significant for altitude straight and level and for glideslope tracking. The other contrasts were not significant except for the control-thiethylperazine contrast for the localizer tracking variable.