Accession Number:

ADA162104

Title:

Systemic Antibody Response of Clinically Characterized Patients with Antigens of Eubacterium brachy Initially and Following Periodontal Therapy,

Descriptive Note:

Corporate Author:

ARMY INST OF DENTAL RESEARCH WASHINGTON DC

Report Date:

1985-11-21

Pagination or Media Count:

32.0

Abstract:

Eubacterium brachy, a Gram positive anaerobic rod, has been implicated by cultural studies to be associated with the microflora of periodontal diseases. Serum samples from 184 clinically characterized patients were evaluated in a standardized enzyme-linked immunosorbent assay ELISA for reactivity to E. brachy antigens. Sera from clinically healthy subjects HS served as controls. Sera from rapidly progressive periodontitis RP patients demonstrated significantly greater reactivity by ELISA than did HS when reactivity with E. brachy antigens was determined P .001. Juvenile periodontitis AP patients did not differ in reactivity by ELISA from HS P .05. Three to four years following successful periodontal therapy, reactivity was not significantly altered in any patient group P .05. The possible significance of these findings and the importance of an extracellular antigen of E. brachy in the immunopathology of periodontal diseases are discussed. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE