Determination of the Chronic Mammalian Toxicological Effects of RDX: (Twenty-Four Month Chronic Toxicity/Carcinogenicity Study of Hexahydro-1,3,5- Trinitro-1,3,5-Triazine (RDX) in the Fischer 344 Rat). Volume 1.
Final rept. Oct 1980-Nov 1983 on Phase 5
IIT RESEARCH INST CHICAGO IL
Pagination or Media Count:
This study was conducted to evaluate the toxicity of the munition compound hexahydro-1,3,5-trinitro-1,3,5-triazine RDX CAS Reg. No. 121-82-4 in Fischer 344 rats when administrated in their diet for up to 24 months. Groups of 75 rats per sex received RDX at doses of 0, 0.3, 1, 5, 8, or 40 mgkgday. Ten rats sexdose were killed following 6 and 12 months on test with surviving animals killed after 24 months of treatment. Toxicologic endpoints included clinical signs, body weights, food consumption, hematology, clinical chemistry, opthalmology, organ weights, and gross and tissue morphology. The major toxic effects observed during the administration of RDX to F344 rats up to 24 months included anemia with secondary splenic lesion, hepatoxicity, possible CNS involvement, cataracts and urogenital lesions. Based on the observance of increased levels of a hemosiderin-like pigment deposited in the spleen a secondary response to a hemolytic-type anemia and suppurative inflammation of the prostate for rats administered 1.5 mgkgday or greater, the no-effect level under conditions of the present study is 0.3 mgkgday.
- SIGNS AND SYMPTOMS
- CENTRAL NERVOUS SYSTEM
- PROSTATE GLAND
- BODY WEIGHT
- URINARY SYSTEM
- CLINICAL MEDICINE
- Medicine and Medical Research