DNA and Protein Studies of HLA Class II Molecules: Their Relationship to T Cell Recognition,
MINNESOTA UNIV MINNEAPOLIS IMMUNOBIOLOGY RESEARCH CENTER
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The HLA-D region, encoding class II antigens, was first defined based on studies of mixed leukocyte culture MLC Bain, et al. 1964 Bach and Hirschhorn, 1964. In our studies with colleagues Amos and Bach, 1968 Bach et al. 1969, we were able to suggest that a genetic region encoding molecules that stimulate proliferation in MLC may be linked to, but separate from, the HLA-A and -B loci, i.e. a region such as HLA-D definitive studies in this regard Yunis and Amos, 1971 established the existence of the HLA-D region. Great advances have been made in our understanding of this region in recent years utilizing both the tools of molecular genetics and studies of proteins encoded by HLA-D genes. A critical bridge that has not yet been completed concerns the relationship of class II genes and protein products to determinants recognized by T lymphocytes, i.e. the cells responding in MLC. Although the emphasis in this review will be on studies of proteins and of DNA, an introduction to this article also includes our current state of knowledge regarding definition of class II products with T lymphocytes. The inclusion in this volume of several articles on the same topic allows a measure of comfort with such an approach.
- Anatomy and Physiology