Hematopoiesis in Conventional Mice after Wound Trauma
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Macrophages, granulocytes, and platelets serve in wound debridement, bacterial neutralization, and homeostasis. Replacement of such cells may involve perturbations in the clonogenic cell populations responsible for replenishing specific adult cell populations. For example, the human blood granulocyte progenitor cell compartment is increased following abdominal hysterectomy. In mice, skin wound trauma produced changes in the proliferative cell compartments of the hematopoietic tissues 24 hrs after injury. In this study we report 1some of our findings on the hematopoietic clonogenic cell changes in conventional mice after trauma and 2 circulating substances which may mediate these changes.
- Medicine and Medical Research