Use of Tyrosine or Foods to Amplify Catecholamine Release.
Interim technical rept. 30 Sep 83-29 Sep 84,
MASSACHUSETTS INST OF TECH CAMBRIDGE LAB OF NEUROENDOCRINE REGULATION
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An experimental system using rat caudate slices was used to measure the effects of tyrosine on neuronal activity. Studies demonstrated the importance of adequate tyrosine in sustaining dopamine release and provide the first evidence that when sufficient experimental tyrosine is not provided, its level within catecholaminergic nerve terminals actually decline. The data suggest that when a group of such neurons undergoes sustained activity, its requirements for tyrosine increase dramatically. In such circumstances, normal levels of plasma tyrosine may be in adequate to sustain function. Author