Accession Number:

ADA160271

Title:

Identification and Quantification of the Water-Soluble Components of JP-4 and a Determination of Their Biological Effects upon Selected Freshwater Organisms.

Descriptive Note:

Final technical rept. 30 Sep 78-27 Feb 84,

Corporate Author:

NORTH DAKOTA STATE UNIV FARGO DEPT OF ZOOLOGY

Personal Author(s):

Report Date:

1985-07-01

Pagination or Media Count:

14.0

Abstract:

This final technical report includes a brief summary of research performed, results obtained, graduate students supported and theses written. One paper published was of a technical nature and describes the use of reversephase C-18 minicolumns for concentrating water soluble hydrocarbons derived from JP-4 jet fuel. Another technical paper using the same technique as the first was used to concentrate water soluble hydrocarbons produced by running an outboard motor in water. Analytical methods used for hydrocarbon separation and identification was GC, GCMS and HPLC. The toxicity of toluene on the fathead minnow was the basis of three papers and a Ph.D. thesis. It was found that the embryo was as sensitive to toluene than was the protolarvae or adult fish. This was determined using 96-hr LC50 tests. An MS thesis was written on the effects of toluene on gill structure in the fathead minnow adult. Little effect of toluene on gill structure was noted. A comparative study on the effects of administration of benzene, toluene and xylene isomeres on their in vitro metabolism and various drug metabolizing enzymes in rat liver, and the covalent binding of toluene to rat liver microsomes has resulted in one Ph.D. thesis and the preparation of three manuscripts for publication. Originator supplied keywords include Enzyme induction Cytochrome P-450 Mixed function oxidase Conjugation Cytochrome c reductase Microsomes Bluegill sunfish.

Subject Categories:

  • Anatomy and Physiology
  • Toxicology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE