Accession Number:

ADA160141

Title:

Molecular Approaches to Selective Immunization.

Descriptive Note:

Final rept. 15 Oct 84-31 Jul 85,

Corporate Author:

MINNESOTA UNIV MINNEAPOLIS

Personal Author(s):

Report Date:

1985-09-30

Pagination or Media Count:

6.0

Abstract:

The sequence polymorphism underlying T lymphocyte recognition as related to the DR alpha beta dimer has been studied using cDNA libraries. DR beta genes form homozygous typing cells expressing the same serologically-defined DR antigen but differing in their Dw subtype, have allowed the pinpointing of single amino acid differences underlying this allotypic variation in some combinations, and two to three amino acid differences in others. Author

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE