Molecular Approaches to Selective Immunization.
Final rept. 15 Oct 84-31 Jul 85,
MINNESOTA UNIV MINNEAPOLIS
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The sequence polymorphism underlying T lymphocyte recognition as related to the DR alpha beta dimer has been studied using cDNA libraries. DR beta genes form homozygous typing cells expressing the same serologically-defined DR antigen but differing in their Dw subtype, have allowed the pinpointing of single amino acid differences underlying this allotypic variation in some combinations, and two to three amino acid differences in others. Author