Accession Number:

ADA159768

Title:

Experimental Argentine Hemorrhagic Fever in Rhesus Macaques: Viral Strain-Dependent Clinical Response,

Descriptive Note:

Corporate Author:

CHICAGO UNIV IL

Report Date:

1985-07-01

Pagination or Media Count:

4.0

Abstract:

Recently, we evaluated rhesus macaques as a potential disease model for AHF. Three of four low-passage strains of Junin virus that were administered to these animals produced severe disease accurately reflected the clinical features of human AHF. These studies establish the utility of Macacca mulatta as a model for human infection with Junin virus and suggest that differences in virus strains may influence patterns of biologic response.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE