Accession Number:

ADA159418

Title:

Health Effects Research on Munition Contaminated Dimethyl Sulfoxide Recrystallization Process Solvent. Phase I Studies.

Descriptive Note:

Final summary rept.

Corporate Author:

ARMY MEDICAL BIOENGINEERING RESEARCH AND DEVELOPMENT LAB FORT DETRICK MD

Report Date:

1985-07-01

Pagination or Media Count:

32.0

Abstract:

Sample material was taken from a dimethylsulfoxide DMSO recrystallization process pilot plant and examined chemically and toxicologically. The work performed to meet Phase I of the research program has been completed. This includes a problem definition study, the chemical and physical characterization of process stream samples and toxicological studies oral LD50 in rats and mice, primary ocular and dermal irritation in rabbits, acute dermal toxicity in rabbits, dermal sensitization in guinea pigs, Ames assay, and mouse lymphoma mammalian cell assay on the recycle solvent and evaporator sludge. Since both the latter were identified as having direct-acting mutagens, research objectives for subsequent phases were changed in order to identify the mutagenic agent in the mixtures. Originator supplied keywords include Acetone Benzothiazole Carcinogenicity Cyclohexanone Hexahydro-1- acetyl-3,5-dinitro-1,3,5-triazine TAX Hexahydro-1,3,5-trinitro-1,3,5-triazine RDX Octahydro-1-acetyl-3,5,7-trinitro-1,3,5,7-tetrazocine SEX Octahydro-1, 3,5,7-tetranitro-1,3,5,7-tetrazocine HMX.

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE