Neurophysiological Bases of Event-Related Potentials.
Annual rept. no. 3, 1 May 84-30 Apr 85,
SRI INTERNATIONAL MENLO PARK CA LIFE SCIENCES DIV
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In order to more fully understand the physiological and psychological significance of event-related potentials, cortical and subcortical recordings are being obtained from monkeys performing in operant-conditioning tasks. Five cynomolgus monkeys were successfully trained in the cued-reaction time task at SRI International and recordings were obtained in several experimental conditions--tone discrimination, variation of interstimulus interval ISI and stimulus proportionality, and administration of atropine. Under some conditions stimulus salience was enhanced, as evidenced by enlarged evoked potentials, when the ISI and stimulus proportionality were altered. The effects of the anticholinergic drug atropine could be attributed to its peripheral effects. Preliminary examination of dynamic intracerebral interactions in one monkey was carried out in collaboration with A. Gevins at the EEG Systems Laboratory, and studies of two monkeys were continued at Stanford in order to study the P300 wave. Five female stump-tailed macaque monkeys were purchased, trained, and implanted and are ready for tone-light pairing and recording.
- Anatomy and Physiology