Accession Number:

ADA158873

Title:

Effect of 3,4-Diaminopyridine on the Survival of Mice Injected with Botulinum Neurotoxin Type A, B, E, or F,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Report Date:

1985-08-16

Pagination or Media Count:

26.0

Abstract:

To determine the efficacy of 3,4-diaminopyridine 3,4-DAP as a potential Treatment for botulism, its effect on the survival times of mice injected with type A, B, E, or F botulinum toxin BoTx was examined. Mice were injected ip with 10, 20 or 40 LD50 of BoTx. Three hr later, when the mice displayed symptoms of botulism, half of each group of mice was treated with 3, 4DAP, and agent which increases nerve-evoked transmitter release. At each dose of type A BoTx tested, 3,4-Dap definitely prolonged survival. In contrast, treatment with the drug did not significantly increase the survival time of mice injected with type B, E, or F BoTx. The differences in efficacy of 3,4-DAP against the four serotypes of BoTx may reflect differences in the molecular mechanism of action among the neurotoxins. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE