Development of an On-Demand, Generic, Drug-Delivery System
Final technical rept. 1 Jun 1984-31 Jul 1985
SOUTHERN RESEARCH INST BIRMINGHAM AL
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The objective of this research program was to develop an on-demand, generic, drug-delivery device. Specifically, this device would provide antidote for extended periods to persons exposed to chemical-warfare agents. The work involved development of a driving mechanism for drug injection, as well as fabrication of the delivery hardware. Three different driving mechanisms for drug injection, as well as fabrication of the delivery hardware. Three different driving mechanisms for controlled drug injection osmotic, enzymatic, and acid base and a working prototype were developed. For ease of evaluation a water- soluble dye was used in place of drug during tests of the prototype. The device was successful in that it delivered a bolus of dye and then sustanined a measured delivery of a different dye over an extended period. The device is also capable of delivering a large variety of soluble agents in a controlled manner, and parameters of the specific driving mechanism may be varied to alter the amount or rate at which the agent is delivered.