Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-35770 Hexahydro-1-((2-Methylcyclohexyl)Carbonyl)-1-H-Azepine.
Rept. for Aug 84-Jun 85 on Phase 1,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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Topical Hazard Evaluations of USDA Candidate Insect Repellent AI3-35770 were performed using New Zealand White rabbits, albino Hartley guinea pigs, and Sprague Dawley rats. Chemical AI3-35770 produced moderate to severe primary dermal irritation and necrosis in rabbits and guinea pigs. These effects were quantitatively worse in rabbits than in guinea pigs. This compound was moderately toxic to rats when given by the oral route.