Accession Number:

ADA156772

Title:

Bioassay of Military Relevant Compounds for Carcinogenic Activity by the Strain A Mouse Lung Tumor Bioassay

Descriptive Note:

Final phase rept. Mar 1983-May 1984

Corporate Author:

MEDICAL COLL OF OHIO AT TOLEDO DEPT OF PATHOLOGY

Personal Author(s):

Report Date:

1985-01-01

Pagination or Media Count:

17.0

Abstract:

Two dye compounds, C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3-C.I. Solvent Yellow 33, utilized in colored smoke grenades, were tested for carcinogenic potential in the strain A mouse lung tumor bioassay. The maximum tolerated dose for each dye was determined to be 25 mgkg. At total doses of 600, 300 and 120 mgkg, C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3-C.I. Solvent Yellow 33 did not produce an increase in the lung tumor response i.e., the percentage of mice with lung tumors or the mean number of lung tumors per mouse when compared to vehicle tricaprylin controls. Therefore, at the dose levels administered both dyes were non-carcinogenic in the strain A mouse lung tumor bioassay under the conditions of the test. At necropsy, mice tested with either compound had significant quantities of accumulated dye in their tissues. This observation suggests that the dyes were either not metabolized or only partially metabolized by the animals.

Subject Categories:

  • Medicine and Medical Research
  • Coatings, Colorants and Finishes

Distribution Statement:

APPROVED FOR PUBLIC RELEASE