Accession Number:

ADA156727

Title:

Study of Toxic and Antigenic Structures of Botulinum Neurotoxins

Descriptive Note:

Annual rept. Mar 1983-Jan 1984

Corporate Author:

WISCONSIN UNIV-MADISON

Personal Author(s):

Report Date:

1984-02-01

Pagination or Media Count:

14.0

Abstract:

Amino acid composition of botulinum neurotoxin NT types A and B were determined. The heavy and light chains of types A and B NT were separated, purified and analyzed for amino acid compositions and partial N-terminal sequence. The single chain type B and E NT were also partially sequenced. Role of tyr, his residues and carboxyl groups in toxicity and antigenicity were determined. Originator supplied keywords include Botulinum neurotoxin heavy chain light chain amino acid composition amino acid sequence subunit chain isolation structure-function relationship selective modification immunogen antiserum.

Subject Categories:

  • Biochemistry
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE